The acute period of the disease begins with the first clinical manifestations (usually one month after infection with pathogenic Brucella species) and lasts no more than one and a half months.

The first and main complaints of patients with an acute form of the disease are severe weakness, decreased ability to work, fever and other symptoms of intoxication. In most patients, a generalized enlargement of the lymph nodes is revealed.

It is important to note the fact that even with severe intoxication and an increase in body temperature, the general well-being of patients remains relatively stable, which is a common cause of errors during diagnosis. Damage to various organs for acute brucellosis is not typical, however, in especially severe cases, already during the first weeks, patients may experience pain in the joints and muscles, damage to the reproductive, nervous and other systems.

A distinctive feature of the subacute form of the disease is the undulating course of fever. The body temperature in such patients is usually elevated, and in most patients there is a fluctuation in the temperature curve even during buy medrol 4mg (in the morning there may be mild subfebrile condition, and in the evening the temperature may exceed 40 degrees).